Why are two mistakes not worse than one?:a proposal for controlling the expected number of false claims

Multiplicity is common in clinical studies and the current standard is to use the familywise error rate to ensure that the errors are kept at a prespecified level. In this paper, we will show that, in certain situations, familywise error rate control does not account for all errors made. To counteract this problem, we propose the use of the expected number of false claims (EFC). We will show that a (weighted) Bonferroni approach can be used to control the EFC, discuss how a study that uses the EFC can be powered for co-primary, exchangeable, and hierarchical endpoints, and show how the weight for the weighted Bonferroni test can be determined in this manner

The QCD sign problem and dynamical simulations of random matrices

At nonzero quark chemical potential dynamical lattice simulations of QCD are hindered by the sign problem caused by the complex fermion determinant. The severity of the sign problem can be assessed by the average phase of the fermion determinant. In an earlier paper we derived a formula for the microscopic limit of the average phase for general topology using chiral random matrix theory. In the current paper we present an alternative derivation of the same quantity, leading to a simpler expression which is also calculable for finite-sized matrices, away from the microscopic limit. We explicitly prove the equivalence of the old and new results in the microscopic limit. The results for finite-sized matrices illustrate the convergence towards the microscopic limit. We compare the analytical results with dynamical random matrix simulations, where various reweighting methods are used to circumvent the sign problem. We discuss the pros and cons of these reweighting methods.Comment: 34 pages, 3 figures, references added, as published in JHE

Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma

<p>Abstract</p> <p>Background</p> <p>B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HLA-DR and the presence of infiltrating lymphocytes and dendritic cells to assess their significance in patients with nasopharyngeal carcinoma (NPC).</p> <p>Methods</p> <p>Expression of CD80, CD86, HLA-DR, S-100 protein and the presence of infiltrating lymphocytes and follicular dendritic reticulum cells were immunohistochemically examined on the paraffin-embedded tissue blocks from newly diagnosed NPC patients (n = 50). The results were correlated with clinical outcome of patients.</p> <p>Results</p> <p>CD80 and CD86 were each expressed in 10 of 50 cases in which they co-expressed in 9 cases. Univariate analysis revealed that patients with CD80/CD86 expression had significantly better overall survival than those without it (P = 0.017), but after adjustment for stage, nodal status, and treatment, the expression of CD80/CD86 did not significantly correlate with overall survival. Expression of HLA-DR and the presence of infiltrating lymphocytes and dendritic cells did not appear to have impact on the survival of patients.</p> <p>Conclusion</p> <p>Expression of CD80 and CD86 costimulatory molecules appears to be a marker of better survival in patient with NPC.</p

Inside-out planet formation. VII. Astrochemical models of protoplanetary disks and implications for planetary compositions

Inside-Out Planet Formation (IOPF) proposes that the abundant systems of close-in Super-Earths and Mini-Neptunes form in situ at the pressure maximum associated with the Dead Zone Inner Boundary (DZIB). We present a model of physical and chemical evolution of protoplanetary disk midplanes that follows gas advection, radial drift of pebbles and gas-grain chemistry to predict abundances from ∼300 au down to the DZIB near 0.2 au. We consider typical disk properties relevant for IOPF, i.e. accretion rates 10−9<m˙/(M⊙yr−1)<10−8 and viscosity parameter α = 10−4, and evolve for fiducial duration of 105 yrs. For outer, cool disk regions, we find that C and up to 90% of O nuclei start locked in CO and O2 ice, which keeps abundances of CO2 and H2O one order of magnitude lower. Radial drift of icy pebbles is influential, with gas-phase abundances of volatiles enhanced up to two orders of magnitude at ice-lines, while the outer disk becomes depleted of dust. Disks with decreasing accretion rates gradually cool, which draws in icelines closer to the star. At ≲ 1 au, advective models yield water-rich gas with C/O ratios ≲ 0.1, which may be inherited by atmospheres of planets forming here via IOPF. For planetary interiors built by pebble accretion, IOPF predicts volatile-poor compositions. However, advectively-enhanced volatile mass fractions of ∼10% can occur at the water ice line

Fiber guiding at the Dirac frequency beyond photonic bandgaps

Light trapping within waveguides is a key practice of modern optics, both scientifically and technologically. Photonic crystal fibers traditionally rely on total internal reflection (index-guiding fibers) or a photonic bandgap (photonic-bandgap fibers) to achieve field confinement. Here, we report the discovery of a new light trapping within fibers by the so-called Dirac point of photonic band structures. Our analysis reveals that the Dirac point can establish suppression of radiation losses and consequently a novel guided mode for propagation in photonic crystal fibers. What is known as the Dirac point is a conical singularity of a photonic band structure where wave motion obeys the famous Dirac equation. We find the unexpected phenomenon of wave localization at this point beyond photonic bandgaps. This guiding relies on the Dirac point rather than total internal reflection or photonic bandgaps, thus providing a sort of advancement in conceptual understanding over the traditional fiber guiding. The result presented here demonstrates the discovery of a new type of photonic crystal fibers, with unique characteristics that could lead to new applications in fiber sensors and lasers. The Dirac equation is a special symbol of relativistic quantum mechanics. Because of the similarity between band structures of a solid and a photonic crystal, the discovery of the Dirac-point-induced wave trapping in photonic crystals could provide novel insights into many relativistic quantum effects of the transport phenomena of photons, phonons, and electrons

Electronic structure and bonding properties of Si-doped hydrogenated amorphous carbon films

[[abstract]]This work investigates the C K-edge x-ray absorption near-edge structure (XANES), valence-band photoelectron spectroscopy (PES), and Fourier transform infrared (FTIR) spectra of Si-doped hydrogenated amorphous carbon films. The C K-edge XANES and valence-band PES spectra indicate that the sp2/sp3 population ratio decreases as the amount of tetramethylsilane vapor precursor increases during deposition, which suggest that Si doping% enhances sp3 and reduces sp2-bonding configurations. FTIR spectra show the formation of a polymeric sp3 C–Hn structure and Si–Hn bonds, which causes the Young’s modulus and hardness of the films to decrease with the increase of the Si content.[[incitationindex]]SCI[[booktype]]紙

Deuterium fractionation across the infrared-dark cloud G034.77−00.55 interacting with the supernova remnant W44

Context. Supernova remnants (SNRs) may regulate star formation in galaxies. For example, SNR-driven shocks may form new molecular gas or compress pre-existing clouds and trigger the formation of new stars. / Aims. To test this scenario, we measured the deuteration of N2H+, DfracN2H+ – a well-studied tracer of pre-stellar cores – across the infrared-dark cloud (IRDC) G034.77-00.55, which is known to be experiencing a shock interaction with the SNR W44. / Methods. We use N2H+ and N2D+J = 1−0 single pointing observations obtained with the 30m antenna at the Instituto de Radioas-tronomia Millimetrica to infer DfracN2H+ towards five positions across the cloud, namely a massive core, different regions across the shock front, a dense clump, an+d ambient gas. / Results. We find DfracN2H+ in the range 0.03−0.1, which is several orders of magnitude larger than the cosmic D/H ratio (~10−5). The DfracN2H+ across the shock front is enhanced by more than a factor of 2 (DfracN2H+ ~ 0.05 - 0.07) with respect to the ambient gas (≤0.03) and simila+r to that measured generally in pre-stellar cores. Indeed, in the massive core and dense clump regions of this IRDC we measure DfracN2H+ ~ 0.01. / Conclusions. We find enhanced deuteration of N2H+ across the region of the shock, that is, at a level that is enhanced with respect to regions of unperturbed gas. It is possible that this has been induced by shock compression, which would then be indirect evidence that the shock is triggering conditions for future star formation. However, since unperturbed dense regions also show elevated levels of deuteration, further, higher-resolution studies are needed to better understand the structure and kinematics of the deuterated material in the shock region; for example, to decipher whether it is still in a relatively diffuse form or is already organised in a population of low-mass pre-stellar cores

Calibration of myocardial T2 and T1 against iron concentration.

BACKGROUND: The assessment of myocardial iron using T2* cardiovascular magnetic resonance (CMR) has been validated and calibrated, and is in clinical use. However, there is very limited data assessing the relaxation parameters T1 and T2 for measurement of human myocardial iron. METHODS: Twelve hearts were examined from transfusion-dependent patients: 11 with end-stage heart failure, either following death (n=7) or cardiac transplantation (n=4), and 1 heart from a patient who died from a stroke with no cardiac iron loading. Ex-vivo R1 and R2 measurements (R1=1/T1 and R2=1/T2) at 1.5 Tesla were compared with myocardial iron concentration measured using inductively coupled plasma atomic emission spectroscopy. RESULTS: From a single myocardial slice in formalin which was repeatedly examined, a modest decrease in T2 was observed with time, from mean (± SD) 23.7 ± 0.93 ms at baseline (13 days after death and formalin fixation) to 18.5 ± 1.41 ms at day 566 (p<0.001). Raw T2 values were therefore adjusted to correct for this fall over time. Myocardial R2 was correlated with iron concentration [Fe] (R2 0.566, p<0.001), but the correlation was stronger between LnR2 and Ln[Fe] (R2 0.790, p<0.001). The relation was [Fe] = 5081•(T2)-2.22 between T2 (ms) and myocardial iron (mg/g dry weight). Analysis of T1 proved challenging with a dichotomous distribution of T1, with very short T1 (mean 72.3 ± 25.8 ms) that was independent of iron concentration in all hearts stored in formalin for greater than 12 months. In the remaining hearts stored for <10 weeks prior to scanning, LnR1 and iron concentration were correlated but with marked scatter (R2 0.517, p<0.001). A linear relationship was present between T1 and T2 in the hearts stored for a short period (R2 0.657, p<0.001). CONCLUSION: Myocardial T2 correlates well with myocardial iron concentration, which raises the possibility that T2 may provide additive information to T2* for patients with myocardial siderosis. However, ex-vivo T1 measurements are less reliable due to the severe chemical effects of formalin on T1 shortening, and therefore T1 calibration may only be practical from in-vivo human studies

Relationship between site of oesophageal cancer and areca chewing and smoking in Taiwan

Among 309 male patients, those who had heavily consumed betel and tobacco were more likely than nonchewers (OR = 2. 91; 95% CI = 1.36-6.25) and nonsmokers (OR = 2.49; 95% CI = 1.02-6.08) to develop cancer in the upper and middle third of the oesophagus, respectively; the effects of alcohol did not dominate in any third